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Frontiers in Endocrinology

Frontiers in Endocrinology

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

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About journal

Scope Field chief editorMission & scopeFactsJournal sectionsOpen access statementCopyright statementQualityFor authors Why submit?Article typesAuthor guidelinesEditor guidelinesPublishing feesSubmission checklistContact editorial office

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Who we are MissionValuesHistoryLeadershipAwardsImpact and progress Frontiers' impactProgress Report 2022All progress reportsPublishing model How we publishOpen accessFee policyPeer reviewResearch TopicsServices SocietiesNational consortiaInstitutional partnershipsCollaboratorsMore from Frontiers Frontiers ForumPress officeCareer opportunitiesContact us All journalsAll articles Submit your research Frontiers in Endocrinology

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

About journal

About journal

Scope Field chief editorMission & scopeFactsJournal sectionsOpen access statementCopyright statementQualityFor authors Why submit?Article typesAuthor guidelinesEditor guidelinesPublishing feesSubmission checklistContact editorial office Frontiers in Endocrinology

Sections

Sections

Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

About journal

About journal

Scope Field chief editorMission & scopeFactsJournal sectionsOpen access statementCopyright statementQualityFor authors Why submit?Article typesAuthor guidelinesEditor guidelinesPublishing feesSubmission checklistContact editorial office Submit  your research Search Frontiers in Endocrinology 5.2 Impact Factor 5.6 CiteScore 146,992 Citations

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Editors See all (6,204) jeff m p holly University of Bristol Bristol, United Kingdom Field Chief Editor

Frontiers in Endocrinology

claus yding andersen University of Copenhagen Copenhagen, Denmark Specialty Chief Editor

Reproduction

antonino belfiore Division of Endocrinology, Department of Clinical and Experimental Medicine, University of Catania Catania, Italy Specialty Chief Editor

Cancer Endocrinology

nienke biermasz Leiden University Leiden, Netherlands Specialty Chief Editor

Pituitary Endocrinology

Articles See all (13,843) Original Research

Accepted on 08 Mar 2024

Relationship between blood cadmium levels and bone mineral density in adults:A cross-sectional study

in Bone Research Yi LeiMeiqian GuoJuan XieXueqing LiuXiang LiYong XuHongwu WangDonghui Zheng Frontiers in Endocrinology doi 10.3389/fendo.2024.1354577 Correction

Accepted on 08 Mar 2024

Corrigendum: Dose-dependent stimulation of human follicular steroidogenesis by a novel rhCG during ovarian stimulation with fixed rFSH dosing

in Reproduction Jane Alrø BøtkjærStine Gry KristensenHanna OlesenPer LarssonBernardette MannaertsClaus Yding Andersen Frontiers in Endocrinology doi 10.3389/fendo.2024.1397017 Review

Accepted on 08 Mar 2024

Endothelial Dysfunction in Vascular Complications of Diabetes: A Comprehensive Review of Mechanisms and Implications

in Diabetes: Molecular Mechanisms Dong-Rong YangMeng-Yan WangCheng-Lin ZhangYu WANG Frontiers in Endocrinology doi 10.3389/fendo.2024.1359255 Review

Accepted on 08 Mar 2024

Maternal nutrient metabolism in the liver during pregnancy

in Reproduction Hongxu FangQingyang LiHaichao WangYing RenLeying ZhangLing Yang Frontiers in Endocrinology doi 10.3389/fendo.2024.1295677 Volumes See all (15)

Volume 15 - 2024

Volume 14 - 2023

Volume 13 - 2022

Volume 12 - 2021

Volume 11 - 2020

Research Topics See all (1,384)

Submission open

G-Protein Coupled Receptors in the Control of Energy Homeostasis and Food Intake Inigo Ruiz de AzuaKen-ichiro NakajimaDoreen Thor

Submission open

Obesity and Metabolism in Endocrine-Related Cancers Chiara LiveraniNatalia Simona Pellegata 112

views

Submission open

Thyroid Hormone Actions in Cancer, volume II Florencia CayrolMaria Del Mar MontesinosHelena Andrea Sterle

Submission open

Vascular Dysfunction and Endocrine Disorders Zhice XuHong Liu 112

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Learn more about Research Topics Footer Guidelines Author guidelinesEditor guidelinesPolicies and publication ethicsFee policy Explore ArticlesResearch Topics Journals Outreach Frontiers Forum Frontiers Policy Labs Frontiers for Young Minds Connect Help centerEmails and alerts Contact us SubmitCareer opportunities Follow us © 2024 Frontiers Media S.A. All rights reserved Privacy policy | Terms and conditions

Frontiers in Endocrinology | About

Frontiers in Endocrinology | About

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Navigation group Top bar navigation Frontiers in Endocrinology

About us

About us

Who we are MissionValuesHistoryLeadershipAwardsImpact and progress Frontiers' impactProgress Report 2022All progress reportsPublishing model How we publishOpen accessFee policyPeer reviewResearch TopicsServices SocietiesNational consortiaInstitutional partnershipsCollaboratorsMore from Frontiers Frontiers ForumPress officeCareer opportunitiesContact us All journalsAll articles Submit your research Search Frontiers in Endocrinology

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Sections

Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

About journal

About journal

Scope Field chief editorMission & scopeFactsJournal sectionsOpen access statementCopyright statementQualityFor authors Why submit?Article typesAuthor guidelinesEditor guidelinesPublishing feesSubmission checklistContact editorial office

About us

About us

Who we are MissionValuesHistoryLeadershipAwardsImpact and progress Frontiers' impactProgress Report 2022All progress reportsPublishing model How we publishOpen accessFee policyPeer reviewResearch TopicsServices SocietiesNational consortiaInstitutional partnershipsCollaboratorsMore from Frontiers Frontiers ForumPress officeCareer opportunitiesContact us All journalsAll articles Submit your research Frontiers in Endocrinology

Sections

Sections

Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

About journal

About journal

Scope Field chief editorMission & scopeFactsJournal sectionsOpen access statementCopyright statementQualityFor authors Why submit?Article typesAuthor guidelinesEditor guidelinesPublishing feesSubmission checklistContact editorial office Frontiers in Endocrinology

Sections

Sections

Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

About journal

About journal

Scope Field chief editorMission & scopeFactsJournal sectionsOpen access statementCopyright statementQualityFor authors Why submit?Article typesAuthor guidelinesEditor guidelinesPublishing feesSubmission checklistContact editorial office Submit  your research Search Main content

Field chief editor

jeff m p holly University of Bristol Bristol, United Kingdom Field Chief Editor

Frontiers in Endocrinology

Mission & scope Frontiers in Endocrinology is a journal that advances our understanding of the endocrine system and publishes research in novel therapies for prevalent health issues such as obesity, diabetes, disorders affecting the reproductive system, and the endocrinology of aging. 

Led by Field Chief Editor Jeff M. P. Holly (University of Bristol, UK), Frontiers in Endocrinology is indexed in MEDLINE, PubMed Central (PMC), Scopus and Web of Science (SCIE), among others, and welcomes research contributions in the various domains of endocrinology, bridging the gap between basic molecular structure and cellular communication, to clinical care. Topics include:

• adrenal endocrinology

• bone research

• cancer endocrinology

• cardiovascular endocrinology 

• cellular endocrinology 

• clinical diabetes

• developmental endocrinology

• diabetes: molecular mechanisms

• endocrinology of aging

• experimental endocrinology

• gut endocrinology

• molecular and structural endocrinology

• neuroendocrine science

• obesity

• pediatric endocrinology 

• pituitary endocrinology

• renal endocrinology

• reproduction

• systems endocrinology

• thyroid endocrinology

• translational endocrinology.

In particular, the journal welcomes submissions which support and advance the UN’s Sustainable Development Goal (SDG), notably SDG 3: good health and well-being, in the effort to further our understanding as well as the prevention and treatment of hormonal disorders.

Manuscripts relating to diseases or disorders that do not relate to hormones are not suitable for publication in this journal. Manuscripts reporting bibliometric analyses will not be considered. In addition, manuscripts consisting solely of bioinformatics analysis of public in silico databases are not considered suitable unless supported by independent experimental verification. Papers reporting findings from Mendelian Randomisation studies need to be accompanied by a completed MR strobe checklist.

Authors are still welcome to submit Systematic Reviews using publicly available data, but these must adhere to the PRISMA guidelines and include a completed checklist with submission and have a conclusion related to endocrinology. Similarly meta-analyses must adhere to the PRISMA extension guidelines and include a completed checklist with submission.

Frontiers in Endocrinology is committed to advancing developments in the field of endocrinology by allowing unrestricted access to articles and communicating scientific knowledge to researchers and the public. This multidisciplinary open-access journal is at the forefront of disseminating impactful discoveries to researchers, academics, clinicians, and the public worldwide.

Frontiers in Endocrinology is member of the Committee on Publication Ethics.

Facts Short name Front. Endocrinol. Abbreviation fendo Electronic ISSN 1664-2392 PMCID All published articles receive a PMCID Impact 5.2 Impact Factor 5.6 CiteScore Indexed in

PubMed, MEDLINE, PubMed Central (PMC), Scopus, Web of Science Science Citation Index Expanded (SCIE), Google Scholar, DOAJ, CrossRef, Chemical Abstracts Service (CAS), Embase, Semantic Scholar, Ulrich's Periodicals Directory, CLOCKSS, EBSCO, OpenAIRE, Zetoc

Journal sections

Frontiers in Endocrinology is composed of the following Specialty

sections:

Adrenal Endocrinology

Bone Research

Cancer Endocrinology

Cardiovascular Endocrinology

Cellular Endocrinology

Clinical Diabetes

Developmental Endocrinology

Diabetes: Molecular Mechanisms

Endocrinology of Aging

Experimental Endocrinology

Gut Endocrinology

Molecular and Structural Endocrinology

Neuroendocrine Science

Obesity

Pediatric Endocrinology

Pituitary Endocrinology

Renal Endocrinology

Reproduction

Systems Endocrinology

Thyroid Endocrinology

Translational Endocrinology

The specialty sections of

Frontiers in Endocrinology welcome submission of the following

article types:

Addendum, Brief Research Report, Case Report, Clinical Trial, Correction, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Policy and Practice Reviews, Review, Study Protocol, Systematic Review, Technology and Code.

When submitting a manuscript to Frontiers in Endocrinology, authors must

submit the material directly to one of the specialty

sections. Manuscripts are peer-reviewed by the

Associate and Review Editors of the respective specialty section.

Open access statement Frontiers' philosophy is that all research is for the benefit of humankind. Research is the product of an investment by society and therefore its fruits should be returned to all people without borders or discrimination, serving society universally and in a transparent fashion. That is why Frontiers provides online free and open access to all of its research publications. For more information on open access click here. Open access funder and institutional mandatesFrontiers is fully compliant with open access mandates, by publishing its articles under the Creative Commons Attribution licence (CC-BY). Funder mandates such as those by the Wellcome Trust (UK), National Institutes of Health (USA) and the Australian Research Council (Australia) are fully compatible with publishing in Frontiers. Authors retain copyright of their work and can deposit their publication in any repository. The work can be freely shared and adapted provided that appropriate credit is given and any changes specified.Copyright statement Under the Frontiers Conditions for Website Use and the Frontiers General Conditions for Authors, authors of articles published in Frontiers journals retain copyright on their articles, except for any third-party images and other materials added by Frontiers, which are subject to copyright of their respective owners. Authors are therefore free to disseminate and re-publish their articles, subject to any requirements of third-party copyright owners and subject to the original publication being fully cited. The ability to copy, download, forward or otherwise distribute any materials is always subject to any copyright notices displayed. Copyright notices must be displayed prominently and may not be obliterated, deleted or hidden, totally or partially.Quality Each Frontiers article strives for the highest quality, thanks to genuinely collaborative interactions between authors, editors and reviewers, who include many of the world's best scientists and scholars. Frontiers is well aware of the potential impact of published research both on future research and on society and, hence, does not support superficial review, light review or no-review publishing models.Frontiers uses the single anonymized peer review model, where the reviewer identity is not made visible to the author, while the author identity is visible to the reviewer, and reviewer and the authors’ identities are visible to the decision-making editor. Reviewers interact with the handling editor and the authors. Editor and reviewer names and affiliations are published on all Frontiers articles.Research must be certified by peers before entering a stream of knowledge that may eventually reach the public - and shape society. Therefore, Frontiers only applies the most rigorous and unbiased reviews, established in the high standards of the Frontiers Review System. Furthermore, only the top certified research, evaluated objectively through quantitative online article level metrics, is disseminated to increasingly wider communities as it gradually climbs the tiers of the Frontiers Tiering System from specialized expert readership towards public understanding.Frontiers has a number of procedures in place to support and ensure the quality of the research articles that are published: 2023

Editorial Board Quality

Only leading experts and established members of the research community are appointed to the Frontiers Editorial Boards. Chief Editors, Associate Editors and Review Editors are all listed with their names and affiliations on the Journal pages and are encouraged to publicly list their publication credentials.

Associate Editor Assignment Quality

Associate Editors oversee the peer-review and take the final acceptance decision on manuscripts. Editorial decision power is distributed in Frontiers, because we believe that many experts within a community should be able to shape the direction of science for the benefit of society.

Submitting authors can choose a preferred Associate Editor to handle their manuscript, because they can judge well who would be an appropriate expert in editing their manuscript. There is no guarantee for this preference of choice, Associate Editors can decline invitations any time, and the handling Associate Editor can also be over-ridden by the Chief Editor before she/he is invited to edit the article or at any other stage.

Associate Editors are mandated to only accept to edit a manuscript if they have no conflicts of interest (as stated here and in their review invitation and assignment emails).

Should it become clear that the Associate Editor has a conflict of interest or is unable to perform the peer-review timely and adequately, a new Associate Editor can be assigned to the manuscript by the Chief Editor, who has full control to intervene in the peer-review process at any time.

The Associate Editor initially checks that the article meets basic quality standards and has no obvious objective errors.

Reviewer Assignment Quality

The Associate Editor can then personally choose and invite the most appropriate reviewers to handle the peer-review of the manuscript, including Review Editors from the board or external reviewers.

The Associate Editor is aided in this by the Frontiers Collaborative Review Forum software and interface, which suggests the most relevant Review Editors based on a match between their expertise and the topic of the manuscript. Associate Editors can however choose any reviewer they deem adequate.

After a certain time frame and if no reviewers have in the meantime been assigned to the manuscript, the Frontiers platform and algorithmic safety-net steps in and invites the most appropriate Review Editors based on constantly updated and improved algorithms that match reviewer expertise with the submitted manuscript.

Review Editors and reviewers are mandated to only accept to review a manuscript if they have no conflicts of interest (as stated here and in their review invitation and assignment emails).

Frontiers algorithms are constantly fine-tuned to better match Review Editors with manuscripts, and additional checks are being coded into the platform, for example regarding conflicts of interest.

Should it become clear that a particular reviewer has a conflict of interest or is unable to perform the peer-review timely and adequately, he or she shall be replaced with an alternative reviewer by the Associate Editor or the Chief Editor, who will be alerted and has full control to intervene into the peer-review at any time.

Independent Review Stage Quality

In the Independent Review Stage the assigned reviewers perform an in-depth review of the article independently of each other to safeguard complete freedom of opinion.

The reviewers are aided by an online standardized review questionnaire – adopted to article types – with the goal to facilitate rigorous evaluation according to objective criteria and the Frontiers Review Guidelines.

Interactive Review Stage Quality

The Associate Editor assesses the reviews and activates the “Interactive Review” – informing the authors of the extent of revisions that are required to address the reviewers’ comments, and starting the Interactive Discussion Forum where authors and also the reviewers get full access to all review reports.

Manuscript and review quality at this stage are enhanced by allowing authors and reviewers to discuss directly with each other in real-time until they reach consensus and a final version of the manuscript is endorsed by the reviewers.

Reviewer identity is protected at this stage to safeguard complete freedom of opinion.

Reviewers can recommend rejection at this stage if their requests to correct objective errors are not being met by the authors or if they deem the article overall of insufficient quality.

Should a dispute arise, authors or reviewers can trigger an arbitration and will alert the Associate Editor, who can assign more reviewers and/or bring the dispute to the attention of the Chief Editor. The Associate Editor can also weigh in on the discussion and is asked to mediate the process to ensure a constructive revision stage.

Decision Stage Quality

The decision to accept an article needs to be unanimous amongst all reviewers and the handling Associate Editor.

The names of the Associate Editor and reviewers are disclosed on published articles to encourage in depth and rigorous reviews, acknowledge work well done on the article and to bring transparency and accountability into peer-review.

Associate Editors can recommend the rejection of an article to the Chief Editor, who needs to check that the authors’ rights have been upheld during the peer-review process, and who can then ultimately reject the article if it is of insufficient quality, has objective errors or if the authors were unreasonably unwilling to address the points raised during the review.

Chief Editors can at any stage of the peer-review step in to comment on the review process, change assigned editors, assign themselves as a reviewer and even as the handling editor for the manuscript, and therefore have full authority and all the mechanisms to act independently in their online editorial office to ensure quality.

Safeguards against Financial Conflicts of Interest

Only leading researchers acting as Associate Editors, who are not part of Frontiers staff, can make acceptance decisions based on reviews performed by external experts acting as Review Editors or reviewers. None have a financial incentive to accept articles, i.e. they are not paid for their role to act as Associate or Review Editors, and any award scheme is not linked to acceptances of manuscripts.

Chief Editors receive an honorarium if their specialty section or field reaches certain submission levels. However, this honorarium is based on the total number of submitted articles during a calendar year, and not the number of accepted articles. Therefore they also have no financial incentive to accept manuscripts.

Post-Publication Stage Quality

The Frontiers platform enables post-publication commenting and discussions on papers and hence the possibility to critically evaluate articles even after the peer-review process.

Frontiers has a community retraction protocol in place to retract papers where serious concerns have been raised and validated by the community that warrant retraction, including ethical concerns, honest errors or scientific misconduct.

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Frontiers in Endocrinology | Articles

Frontiers in Endocrinology | Articles

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Who we are MissionValuesHistoryLeadershipAwardsImpact and progress Frontiers' impactProgress Report 2022All progress reportsPublishing model How we publishOpen accessFee policyPeer reviewResearch TopicsServices SocietiesNational consortiaInstitutional partnershipsCollaboratorsMore from Frontiers Frontiers ForumPress officeCareer opportunitiesContact us All journalsAll articles Submit your research Search Frontiers in Endocrinology

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

About journal

About journal

Scope Field chief editorMission & scopeFactsJournal sectionsOpen access statementCopyright statementQualityFor authors Why submit?Article typesAuthor guidelinesEditor guidelinesPublishing feesSubmission checklistContact editorial office

About us

About us

Who we are MissionValuesHistoryLeadershipAwardsImpact and progress Frontiers' impactProgress Report 2022All progress reportsPublishing model How we publishOpen accessFee policyPeer reviewResearch TopicsServices SocietiesNational consortiaInstitutional partnershipsCollaboratorsMore from Frontiers Frontiers ForumPress officeCareer opportunitiesContact us All journalsAll articles Submit your research Frontiers in Endocrinology

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

About journal

About journal

Scope Field chief editorMission & scopeFactsJournal sectionsOpen access statementCopyright statementQualityFor authors Why submit?Article typesAuthor guidelinesEditor guidelinesPublishing feesSubmission checklistContact editorial office Frontiers in Endocrinology

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

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Articles Original Research

Accepted on 08 Mar 2024

Relationship between blood cadmium levels and bone mineral density in adults:A cross-sectional study

in Bone Research Yi LeiMeiqian GuoJuan XieXueqing LiuXiang LiYong XuHongwu WangDonghui Zheng Frontiers in Endocrinology doi 10.3389/fendo.2024.1354577 Correction

Accepted on 08 Mar 2024

Corrigendum: Dose-dependent stimulation of human follicular steroidogenesis by a novel rhCG during ovarian stimulation with fixed rFSH dosing

in Reproduction Jane Alrø BøtkjærStine Gry KristensenHanna OlesenPer LarssonBernardette MannaertsClaus Yding Andersen Frontiers in Endocrinology doi 10.3389/fendo.2024.1397017 Review

Accepted on 08 Mar 2024

Endothelial Dysfunction in Vascular Complications of Diabetes: A Comprehensive Review of Mechanisms and Implications

in Diabetes: Molecular Mechanisms Dong-Rong YangMeng-Yan WangCheng-Lin ZhangYu WANG Frontiers in Endocrinology doi 10.3389/fendo.2024.1359255 Review

Accepted on 08 Mar 2024

Maternal nutrient metabolism in the liver during pregnancy

in Reproduction Hongxu FangQingyang LiHaichao WangYing RenLeying ZhangLing Yang Frontiers in Endocrinology doi 10.3389/fendo.2024.1295677 Original Research

Accepted on 08 Mar 2024

Causal Association between Thyroid Dysfunction and Sepsis: A Two-Sample Mendelian Randomization Study

in Systems Endocrinology Junbin HongLian ZhangYanni LaiXinying ChenYiting ChenJinghua Yang Frontiers in Endocrinology doi 10.3389/fendo.2024.1348248 Original Research

Accepted on 08 Mar 2024

Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study

in Cardiovascular Endocrinology Ting DongWeiquan LinQin ZhouYunou YangXiangyi LiuJiamin ChenHui LiuCaixia Zhang Frontiers in Endocrinology doi 10.3389/fendo.2024.1302296 Original Research

Published on 08 Mar 2024

Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms

in Cancer Endocrinology Chaoyu PangYongzheng LiMing ShiZhiyao FanXin GaoYufan MengShujie LiuChanghao GaoPeng SuXiao Wang Frontiers in Endocrinology doi 10.3389/fendo.2024.1281622 Original Research

Published on 08 Mar 2024

Prediction of immunotherapy response in idiopathic membranous nephropathy using deep learning-pathological and clinical factors

in Renal Endocrinology Xuejiao WeiMengtuan LongZhongyu FanYue HouXiaoyu ZhuZhihui QuYujun Du Frontiers in Endocrinology doi 10.3389/fendo.2024.1328579 Original Research

Published on 08 Mar 2024

Effectiveness and safety of glucagon-like peptide 1 receptor agonists in patients with type 2 diabetes: evidence from a retrospective real-world study

in Clinical Diabetes Yan JiangHan-Sheng BaiGuo-Xin LiuShi-Yi WangLi YinZhao-Ting HouChen-Yang ZhaoGuang-Jun Fan Frontiers in Endocrinology doi 10.3389/fendo.2024.1347684 Original Research

Published on 08 Mar 2024

Quantitative assessment of OCT and OCTA parameters in diabetic retinopathy with and without macular edema: single-center cross-sectional analysis

in Clinical Diabetes Yanyan CuiDongfan FengChanglong WuPing WangRuoxi CuiXiaokun WangWeiwei ChangWeiwei ShangBojun ZhaoJing Liu Frontiers in Endocrinology doi 10.3389/fendo.2023.1275200 Case Report

Published on 08 Mar 2024

Semaglutide as a potential therapeutic alternative for HNF1B-MODY: a case study

in Pediatric Endocrinology Angham AlmutairBeshaier Almulhem Frontiers in Endocrinology doi 10.3389/fendo.2024.1294264 130

views

Original Research

Published on 08 Mar 2024

Treg cells as a protective factor for Hashimoto`s thyroiditis: a Mendelian randomization study

in Thyroid Endocrinology Jinzhou GuoGao SiFuchun Si Frontiers in Endocrinology doi 10.3389/fendo.2024.1347695 Original Research

Published on 08 Mar 2024

Phthalate metabolites and sex steroid hormones in relation to obesity in US adults: NHANES 2013-2016

in Obesity Jiechang ZhangWen GuShilei ZhaiYumeng LiuChengcheng YangLishun XiaoDing Chen Frontiers in Endocrinology doi 10.3389/fendo.2024.1340664 Mini Review

Published on 08 Mar 2024

Anti-osteoporotic treatments in the era of non-alcoholic fatty liver disease: friend or foe

in Obesity Maria Eleni ChondrogianniIoannis KyrouTheodoros AndroutsakosChristina-Maria FlessaEvangelos MenenakosKamaljit Kaur ChathaYekaterina ArananAthanasios G. PapavassiliouEva KassiHarpal S. Randeva Frontiers in Endocrinology doi 10.3389/fendo.2024.1344376 174

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Original Research

Published on 08 Mar 2024

Comparison of seven anthropometric indexes to predict hypertension plus hyperuricemia among U.S. adults

in Obesity Ye LiLing Zeng Frontiers in Endocrinology doi 10.3389/fendo.2024.1301543 116

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Original Research

Published on 08 Mar 2024

Appropriate whole genome amplification and pathogenic loci detection can improve the accuracy of preimplantation genetic diagnosis for deletional α-thalassemia

in Reproduction Yueyun LanHong ZhouSheng HeJinhui ShuLifang LiangHongwei WeiJingsi LuoCaizhu WangXin ZhaoQingming Qiu Frontiers in Endocrinology doi 10.3389/fendo.2023.1176063 Footer Guidelines Author guidelinesEditor guidelinesPolicies and publication ethicsFee policy Explore ArticlesResearch Topics Journals Outreach Frontiers Forum Frontiers Policy Labs Frontiers for Young Minds Connect Help centerEmails and alerts Contact us SubmitCareer opportunities Follow us © 2024 Frontiers Media S.A. All rights reserved Privacy policy | Terms and conditions

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

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Volume 15 - 2024

Original Research

Accepted on 08 Mar 2024

Relationship between blood cadmium levels and bone mineral density in adults:A cross-sectional study Yi LeiMeiqian GuoJuan XieXueqing LiuXiang LiYong XuHongwu WangDonghui Zheng Frontiers in Endocrinology doi 10.3389/fendo.2024.1354577 Correction

Accepted on 08 Mar 2024

Corrigendum: Dose-dependent stimulation of human follicular steroidogenesis by a novel rhCG during ovarian stimulation with fixed rFSH dosing Jane Alrø BøtkjærStine Gry KristensenHanna OlesenPer LarssonBernardette MannaertsClaus Yding Andersen Frontiers in Endocrinology doi 10.3389/fendo.2024.1397017 Review

Accepted on 08 Mar 2024

Endothelial Dysfunction in Vascular Complications of Diabetes: A Comprehensive Review of Mechanisms and Implications Dong-Rong YangMeng-Yan WangCheng-Lin ZhangYu WANG Frontiers in Endocrinology doi 10.3389/fendo.2024.1359255 Review

Accepted on 08 Mar 2024

Maternal nutrient metabolism in the liver during pregnancy Hongxu FangQingyang LiHaichao WangYing RenLeying ZhangLing Yang Frontiers in Endocrinology doi 10.3389/fendo.2024.1295677 Original Research

Accepted on 08 Mar 2024

Causal Association between Thyroid Dysfunction and Sepsis: A Two-Sample Mendelian Randomization Study Junbin HongLian ZhangYanni LaiXinying ChenYiting ChenJinghua Yang Frontiers in Endocrinology doi 10.3389/fendo.2024.1348248 Original Research

Accepted on 08 Mar 2024

Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study Ting DongWeiquan LinQin ZhouYunou YangXiangyi LiuJiamin ChenHui LiuCaixia Zhang Frontiers in Endocrinology doi 10.3389/fendo.2024.1302296 Original Research

Published on 08 Mar 2024

Expression and clinical value of CXCR4 in high grade gastroenteropancreatic neuroendocrine neoplasms Chaoyu PangYongzheng LiMing ShiZhiyao FanXin GaoYufan MengShujie LiuChanghao GaoPeng SuXiao Wang Frontiers in Endocrinology doi 10.3389/fendo.2024.1281622 Original Research

Published on 08 Mar 2024

Prediction of immunotherapy response in idiopathic membranous nephropathy using deep learning-pathological and clinical factors Xuejiao WeiMengtuan LongZhongyu FanYue HouXiaoyu ZhuZhihui QuYujun Du Frontiers in Endocrinology doi 10.3389/fendo.2024.1328579 Original Research

Published on 08 Mar 2024

Effectiveness and safety of glucagon-like peptide 1 receptor agonists in patients with type 2 diabetes: evidence from a retrospective real-world study Yan JiangHan-Sheng BaiGuo-Xin LiuShi-Yi WangLi YinZhao-Ting HouChen-Yang ZhaoGuang-Jun Fan Frontiers in Endocrinology doi 10.3389/fendo.2024.1347684 Case Report

Published on 08 Mar 2024

Semaglutide as a potential therapeutic alternative for HNF1B-MODY: a case study Angham AlmutairBeshaier Almulhem Frontiers in Endocrinology doi 10.3389/fendo.2024.1294264 130

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Original Research

Published on 08 Mar 2024

Treg cells as a protective factor for Hashimoto`s thyroiditis: a Mendelian randomization study Jinzhou GuoGao SiFuchun Si Frontiers in Endocrinology doi 10.3389/fendo.2024.1347695 Original Research

Published on 08 Mar 2024

Phthalate metabolites and sex steroid hormones in relation to obesity in US adults: NHANES 2013-2016 Jiechang ZhangWen GuShilei ZhaiYumeng LiuChengcheng YangLishun XiaoDing Chen Frontiers in Endocrinology doi 10.3389/fendo.2024.1340664 Mini Review

Published on 08 Mar 2024

Anti-osteoporotic treatments in the era of non-alcoholic fatty liver disease: friend or foe Maria Eleni ChondrogianniIoannis KyrouTheodoros AndroutsakosChristina-Maria FlessaEvangelos MenenakosKamaljit Kaur ChathaYekaterina ArananAthanasios G. PapavassiliouEva KassiHarpal S. Randeva Frontiers in Endocrinology doi 10.3389/fendo.2024.1344376 174

views

Original Research

Published on 08 Mar 2024

Comparison of seven anthropometric indexes to predict hypertension plus hyperuricemia among U.S. adults Ye LiLing Zeng Frontiers in Endocrinology doi 10.3389/fendo.2024.1301543 116

views

Volume 14 - 2023

Original Research

Published on 08 Mar 2024

Quantitative assessment of OCT and OCTA parameters in diabetic retinopathy with and without macular edema: single-center cross-sectional analysis Yanyan CuiDongfan FengChanglong WuPing WangRuoxi CuiXiaokun WangWeiwei ChangWeiwei ShangBojun ZhaoJing Liu Frontiers in Endocrinology doi 10.3389/fendo.2023.1275200 Original Research

Published on 08 Mar 2024

Appropriate whole genome amplification and pathogenic loci detection can improve the accuracy of preimplantation genetic diagnosis for deletional α-thalassemia Yueyun LanHong ZhouSheng HeJinhui ShuLifang LiangHongwei WeiJingsi LuoCaizhu WangXin ZhaoQingming Qiu Frontiers in Endocrinology doi 10.3389/fendo.2023.1176063 Footer Guidelines Author guidelinesEditor guidelinesPolicies and publication ethicsFee policy Explore ArticlesResearch Topics Journals Outreach Frontiers Forum Frontiers Policy Labs Frontiers for Young Minds Connect Help centerEmails and alerts Contact us SubmitCareer opportunities Follow us © 2024 Frontiers Media S.A. All rights reserved Privacy policy | Terms and conditions

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

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Who we are MissionValuesHistoryLeadershipAwardsImpact and progress Frontiers' impactProgress Report 2022All progress reportsPublishing model How we publishOpen accessFee policyPeer reviewResearch TopicsServices SocietiesNational consortiaInstitutional partnershipsCollaboratorsMore from Frontiers Frontiers ForumPress officeCareer opportunitiesContact us All journalsAll articles Submit your research Frontiers in Endocrinology

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

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Adrenal EndocrinologyBone ResearchCancer EndocrinologyCardiovascular EndocrinologyCellular EndocrinologyClinical DiabetesDevelopmental EndocrinologyDiabetes: Molecular MechanismsEndocrinology of AgingExperimental EndocrinologyGut EndocrinologyMolecular and Structural EndocrinologyNeuroendocrine ScienceObesityPediatric EndocrinologyPituitary EndocrinologyRenal EndocrinologyReproductionSystems EndocrinologyThyroid EndocrinologyTranslational Endocrinology ArticlesResearch TopicsEditorial Board

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Scope Field chief editorMission & scopeFactsJournal sectionsOpen access statementCopyright statementQualityFor authors Why submit?Article typesAuthor guidelinesEditor guidelinesPublishing feesSubmission checklistContact editorial office Submit  your research Search Author guidelinesGeneral standardsArticle typeFrontiers requires authors to select the appropriate article type for their manuscript and to comply with the article type descriptions defined in the journal's 'Article types' page, which can be seen from the 'For authors' menu on every Frontiers journal page. Please pay close attention to the word count limits.TemplatesIf working with Word please use our Word templates. If you wish to submit your article as LaTeX, we recommend our LaTeX templates.

For LaTeX files, please ensure all relevant manuscript files are uploaded: .tex file, PDF, and .bib file (if the bibliography is not already included in the .tex file).During the interactive review, authors are encouraged to upload versions using track changes. Editors and reviewers can only download the PDF file of the submitted manuscript.Manuscript lengthFrontiers encourages the authors to closely follow the article word count lengths given in the 'Article types' page of the journals. The manuscript length includes only the main body of the text, footnotes, and all citations within it, and excludes the abstract, section titles, figure and table captions, funding statement, acknowledgments, and references in the bibliography. Please indicate the number of words and the number of figures and tables included in your manuscript on the first page.Language editingFrontiers requires manuscripts submitted to meet international English language standards to be considered for publication.For authors who would like their manuscript to receive language editing or proofreading to improve the clarity of the manuscript and help highlight their research, Frontiers recommends the language-editing services provided by the following external partners.Note that sending your manuscript for language editing does not imply or guarantee that it will be accepted for publication by a Frontiers journal. Editorial decisions on the scientific content of a manuscript are independent of whether it has received language editing or proofreading by these partner services or other services.Editage

Frontiers is pleased to recommend the language-editing service provided by our external partner Editage to authors who believe their manuscripts would benefit from professional editing. These services may be particularly useful for researchers for whom English is not the primary language. They can help to improve the grammar, syntax, and flow of your manuscript prior to submission. Frontiers authors will receive a 10% discount by visiting the following link: editage.com/frontiers.The Charlesworth Group

Frontiers recommends the Charlesworth Group's author services, who has a long-standing track record in language editing and proofreading. This is a third-party service for which Frontiers authors will receive a 10% discount by visiting the following link: www.cwauthors.com/frontiers.Frontiers推荐您使用在英语语言编辑和校对领域具有悠久历史和良好口碑的查尔斯沃思作者服务。此项服务由第三方为您提供,Frontiers中国作者通过此链接提交稿件时可获得10%的特别优惠: www.cwauthors.com.cn/frontiersLanguage styleThe default language style at Frontiers is American English. If you prefer your article to be formatted in British English, please specify this on the first page of your manuscript. For any questions regarding style, Frontiers recommends authors to consult the Chicago Manual of Style.Search engine optimization (SEO)There are a few simple ways to maximize your article's discoverability. Follow the steps below to improve the search results of your article:include a few of your article's keywords in the title of the articledo not use long article titlespick 5-8 keywords using a mix of generic and more specific terms on the article subject(s)use the maximum amount of keywords in the first two sentences of the abstractuse some of the keywords in level 1 headings.CrossMark policyCrossMark is a multi-publisher initiative to provide a standard way for readers to locate the current version of a piece of content. By applying the CrossMark logo Frontiers is committed to maintaining the content it publishes and to alerting readers to changes if and when they occur. Clicking on the CrossMark logo will tell you the current status of a document and may also give you additional publication record information about the document.TitleThe title should be concise, omitting terms that are implicit and, where possible, be a statement of the main result or conclusion presented in the manuscript. Abbreviations should be avoided within the title.Witty or creative titles are welcome, but only if relevant and within measure. Consider if a title meant to be thought-provoking might be misinterpreted as offensive or alarming. In extreme cases, the editorial office may veto a title and propose an alternative.

Authors should avoid:titles that are a mere question without giving the answerunambitious titles, for example starting with 'Towards,' 'A description of,' 'A characterization of' or 'Preliminary study on'vague titles, for example starting with 'Role of', 'Link between', or 'Effect of' that do not specify the role, link, or effectincluding terms that are out of place, for example the taxonomic affiliation apart from species name.For Corrigenda, General Commentaries, and Editorials, the title of your manuscript should have the following format:'Corrigendum: Title of Original Article'General Commentaries:

'Commentary: Title of Original Article'

'Response: Commentary: Title of Original Article''Editorial: Title of Research Topic'The running title should be a maximum of five words in length.Authors and affiliationsAll names are listed together and separated by commas. Provide exact and correct author names as these will be indexed in official archives. Affiliations should be keyed to the author's name with superscript numbers and be listed as follows:Laboratory, Institute, Department, Organization, City, State abbreviation (only for United States, Canada, and Australia), and Country (without detailed address information such as city zip codes or street names).Example: Max Maximus1

1 Department of Excellence, International University of Science, New York, NY, United States.CorrespondenceThe corresponding author(s) should be marked with an asterisk in the author list. Provide the exact contact email address of the corresponding author(s) in a separate section.

Example: Max Maximus*

maximus@iuscience.edu

If any authors wish to include a change of address, list the present address(es) below the correspondence details using a unique superscript symbol keyed to the author(s) in the author list.Equal contributionsThe authors who have contributed equally should be marked with a symbol (†) in the author list of the doc/latex and pdf files of the manuscript uploaded at submission.Please use the appropriate standard statement(s) to indicate equal contributions:Equal contribution: These authors contributed equally to this workFirst authorship: These authors share first authorshipSenior authorship: These authors share senior authorshipLast authorship: These authors share last authorshipEqual contribution and first authorship: These authors contributed equally to this work and share first authorshipEqual contribution and senior authorship: These authors contributed equally to this work and share senior authorshipEqual contribution and last authorship: These authors contributed equally to this work and share last authorshipExample: Max Maximus 1†, John Smith2† and Barbara Smith1

†These authors contributed equally to this work and share first authorshipConsortium/group and collaborative authorsConsortium/group authorship should be listed in the manuscript with the other author(s).In cases where authorship is retained by the consortium/group, the consortium/group should be listed as an author separated by a comma or 'and'. The consortium/group name will appear in the author list, in the citation, and in the copyright. If provided, the consortium/group members will be listed in a separate section at the end of the article.For the collaborators of the consortium/group to be indexed in PubMed, they do not have to be inserted in the Frontiers submission system individually. However, in the manuscript itself, provide a section with the name of the consortium/group as the heading followed by the list of collaborators, so they can be tagged accordingly and indexed properly.Example: John Smith, Barbara Smith and The Collaborative Working Group.

In cases where work is presented by the author(s) on behalf of a consortium/group, it should be included in the author list separated with the wording 'for' or 'on behalf of.' The consortium/group will not retain authorship and will only appear in the author list.Example: John Smith and Barbara Smith on behalf of The Collaborative Working Group.AbstractAs a primary goal, the abstract should make the general significance and conceptual advance of the work clearly accessible to a broad readership. The  abstract should be no longer than a single paragraph and should be structured, for example, according to the IMRAD format. For the specific structure of the abstract, authors should follow the requirements of the article type or journal to which they're submitting. Minimize the use of abbreviations and do not cite references, figures or tables.

For clinical trial articles, please include the unique identifier and the URL of the publicly-accessible website on which the trial is registered.KeywordsAll article types require a minimum of five and a maximum of eight keywords.TextThe entire document should be single-spaced and must contain page and line numbers in order to facilitate the review process. The manuscript should be written using either Word or LaTeX. See above for templates.NomenclatureThe use of abbreviations should be kept to a minimum. Non-standard abbreviations should be avoided unless they appear at least four times, and must be defined upon first use in the main text. Consider also giving a list of non-standard abbreviations at the end, immediately before the acknowledgments.Equations should be inserted in editable format from the equation editor.Italicize gene symbols and use the approved gene nomenclature where it is available. For human genes, please refer to the HUGO Gene Nomenclature Committee (HGNC). New symbols for human genes should be submitted to the HGNC here. Common alternative gene aliases may also be reported, but should not be used alone in place of the HGNC symbol. Nomenclature committees for other species are listed here. Protein products are not italicized.We encourage the use of Standard International Units in all manuscripts.Chemical compounds and biomolecules should be referred to using systematic nomenclature, preferably using the recommendations by the International Union of Pure and Applied Chemistry (IUPAC).Astronomical objects should be referred to using the nomenclature given by the International Astronomical Union (IAU) provided here.Life Science Identifiers (LSIDs) for ZOOBANK registered names or nomenclatural acts should be listed in the manuscript before the keywords. An LSID is represented as a uniform resource name (URN) with the following format: urn:lsid:::[:]For more information on LSIDs please see the 'Code' section of our polices and publication ethics.SectionsThe manuscript is organized by headings and subheadings. The section headings should be those appropriate for your field and the research itself. You may insert up to 5 heading levels into your manuscript (i.e.,: 3.2.2.1.2 Heading Title).For Original Research articles, it is recommended to organize your manuscript in the following sections or their equivalents for your field.Introduction

Succinct, with no subheadings.Materials and methods

This section may be divided by subheadings and should contain sufficient detail so that when read in conjunction with cited references, all procedures can be repeated. For experiments reporting results on animal or human subject research, an ethics approval statement should be included in this section (for further information, see the 'Bioethics' section of our polices and publication ethics.)Results

This section may be divided by subheadings. Footnotes should not be used and must be transferred to the main text.Discussion

This section may be divided by subheadings. Discussions should cover the key findings of the study: discuss any prior research related to the subject to place the novelty of the discovery in the appropriate context, discuss the potential shortcomings and limitations on their interpretations, discuss their integration into the current understanding of the problem and how this advances the current views, speculate on the future direction of the research, and freely postulate theories that could be tested in the future.For further information, please check the descriptions defined in the journal's 'Article types' page, in the 'For authors' menu on every journal page.AcknowledgmentsThis is a short text to acknowledge the contributions of specific colleagues, institutions, or agencies that aided the efforts of the authors. Should the content of the manuscript have previously appeared online, such as in a thesis or preprint, this should be mentioned here, in addition to listing the source within the reference list.Scope statementWhen you submit your manuscript, you will be required to summarize in 200 words your manuscript's scope and its relevance to the journal and/or specialty section you're submitting to. The aim is to convey to editors and reviewers how the contents of your manuscript fit within the selected journal's scope.

This statement will not be published with your article if it is accepted for publication. The information will be used during the initial validation and review processes to assess whether the manuscript is a suitable fit for the chosen journal and specialty.

We encourage you to consider carefully where to submit your manuscript, as submissions to an unsuitable journal or specialty will result in delays and increase the likelihood of manuscript rejection.

If you are submitting to a Research Topic, please also clarify how your submission is suited to the specific topic.Figure and table guidelinesCC-BY licenseAll figures, tables, and images will be published under a Creative Commons CC-BY license, and permission must be obtained for use of copyrighted material from other sources (including re-published/adapted/modified/partial figures and images from the internet). It is the responsibility of the authors to acquire the licenses, follow any citation instructions requested by third-party rights holders, and cover any supplementary charges.For additional information, please see the 'Image manipulation' section of our polices and publication ethics.Figure requirements and style guidelinesFrontiers requires figures to be submitted individually, in the same order as they are referred to in the manuscript; the figures will then be automatically embedded at the end of the submitted manuscript. Kindly ensure that each figure is mentioned in the text and in numerical order.For figures with more than one panel, panels should be clearly indicated using labels (A), (B), (C), (D), etc. However, do not embed the part labels over any part of the image, these labels will be replaced during typesetting according to Frontiers' journal style. For graphs, there must be a self-explanatory label (including units) along each axis.For LaTeX files, figures should be included in the provided PDF. In case of acceptance, our production office might require high-resolution files of the figures included in the manuscript in EPS, JPEG or TIF/TIFF format.To upload more than one figure at a time, save the figures (labeled in order of appearance in the manuscript) in a zip file and upload them as 'Supplementary Material Presentation.'Please note that figures not in accordance with the guidelines will cause substantial delay during the production process.CaptionsCaptions should be preceded by the appropriate label, for example 'Figure 1.' Figure captions should be placed at the end of the manuscript. Figure panels are referred to by bold capital letters in brackets: (A), (B), (C), (D), etc.Image size and resolution requirementsFigures should be prepared with the PDF layout in mind. Individual figures should not be longer than one page and with a width that corresponds to 1 column (85 mm) or 2 columns (180 mm).All images must have a resolution of 300 dpi at final size. Check the resolution of your figure by enlarging it to 150%. If the image appears blurry, jagged, or has a stair-stepped effect, the resolution is too low.The text should be legible and of high quality. The smallest visible text should be no less than eight points in height when viewed at actual size.Solid lines should not be broken up. Any lines in the graphic should be no smaller than two points wide.Please note that saving a figure directly as an image file (JPEG, TIF) can greatly affect the resolution of your image. To avoid this, one option is to export the file as PDF, then convert into TIFF or EPS using a graphics software.Format and color image modeThe following formats are accepted: TIF/TIFF (.tif/.tiff), JPEG (.jpg), and EPS (.eps) (upon acceptance). Images must be submitted in the color mode RGB.Chemical structuresChemical structures should be prepared using ChemDraw or a similar program. If working with ChemDraw please use our ChemDraw template. If working with another program please follow the guidelines below.Drawing settings: chain angle, 120° bond spacing, 18% width; fixed length, 14.4 pt; bold width, 2.0 pt; line width, 0.6 pt; margin width, 1.6 pt; hash spacing, 2.5 pt. Scale 100% Atom Label settings: font, Arial; size, 8 ptAssign all chemical compounds a bold, Arabic numeral in the order in which the compounds are presented in the manuscript text.Table requirements and style guidelinesTables should be inserted at the end of the manuscript in an editable format. If you use a word processor, build your table in Word. If you use a LaTeX processor, build your table in LaTeX. An empty line should be left before and after the table.Table captions must be placed immediately before the table. Captions should be preceded by the appropriate label, for example 'Table 1.' Please use only a single paragraph for the caption.Kindly ensure that each table is mentioned in the text and in numerical order.Please note that large tables covering several pages cannot be included in the final PDF for formatting reasons. These tables will be published as supplementary material.Tables which are not according to the above guidelines will cause substantial delay during the production process.AccessibilityFrontiers encourages authors to make the figures and visual elements of their articles accessible for the visually impaired. An effective use of color can help people with low visual acuity, or color blindness, understand all the content of an article.These guidelines are easy to implement and are in accordance with the W3C Web Content Accessibility Guidelines (WCAG 2.1), the standard for web accessibility best practices.Ensure sufficient contrast between text and its background

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Christensen S, Oppacher F. An analysis of Koza's computational effort statistic for genetic programming. In: Foster JA, editor. Genetic Programming. EuroGP 2002: Proceedings of the 5th European Conference on Genetic Programming; 2002 Apr 3–5; Kinsdale, Ireland. Berlin: Springer (2002). p. 182–91.Website

World Health Organization. E. coli (2018). https://www.who.int/news-room/fact-sheets/detail/e-coli [Accessed March 15, 2018].Patent

Pagedas AC, inventor; Ancel Surgical R&D Inc., assignee. Flexible Endoscopic Grasping and Cutting Device and Positioning Tool Assembly. United States patent US 20020103498 (2002).Data

Perdiguero P, Venturas M, Cervera MT, Gil L, Collada C. Data from: Massive sequencing of Ulms minor's transcriptome provides new molecular tools for a genus under the constant threat of Dutch elm disease. Dryad Digital Repository. (2015) http://dx.doi.org/10.5061/dryad.ps837Theses and dissertationsSmith, J. (2008) Post-structuralist discourse relative to phenomological pursuits in the deconstructivist arena. [dissertation/master’s thesis]. [Chicago (IL)]: University of ChicagoPreprint

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Frontiers in Endocrinology | Systems Endocrinology

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Editors See all (159) darko stefanovski University of Pennsylvania Philadelphia, United States Specialty Chief Editor

Systems Endocrinology

joseph beyene McMaster University Hamilton, Canada Associate Editor

Systems Endocrinology

antonio brunetti Magna Græcia University Catanzaro, Italy Associate Editor

Systems Endocrinology

lisa m butler University of Adelaide Adelaide, Australia Associate Editor

Systems Endocrinology

Articles See all (323) Original Research

Accepted on 08 Mar 2024

Causal Association between Thyroid Dysfunction and Sepsis: A Two-Sample Mendelian Randomization Study

in Systems Endocrinology Junbin HongLian ZhangYanni LaiXinying ChenYiting ChenJinghua Yang Frontiers in Endocrinology doi 10.3389/fendo.2024.1348248 Editorial

Published on 07 Mar 2024

Editorial: Benefits and risks of drug combination therapy for chronic metabolic diseases

in Systems Endocrinology Tingting QiuDan Yan Frontiers in Endocrinology doi 10.3389/fendo.2024.1390248 Original Research

Published on 05 Mar 2024

Independent associations of serum calcium with or without albumin adjustment and serum phosphorus with nonalcoholic fatty liver disease: results from NHANES 1999-2018

in Systems Endocrinology Haolong QiBin WangLei Zhu Frontiers in Endocrinology doi 10.3389/fendo.2024.1323990 192

views

Original Research

Accepted on 04 Mar 2024

Assessing the Causal Relationship between Gut Microbiota and Diabetic Nephropathy: Insights from Two-Sample Mendelian Randomization

in Systems Endocrinology Yipeng FangYunfei ZhangQian LiuZenan ZhengChunhong RenXin Zhang Frontiers in Endocrinology doi 10.3389/fendo.2024.1329954 Research Topics See all (46)

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Genetics and multi-omics approach in metabolic liver disorders Omar Ramos-LopezPrabu ParamasivamSathishkumar Chandrakumar 236

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Next generation of omics analysis to study lipid-rich tissues Tatjana SajicAndrew SmithVanna DentiIsabella Piga 1,594

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1

article

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Benefits and Risks of Drug Combination Therapy for Chronic Metabolic Diseases Dan YanHao LinShusen SunMondher Toumi 18,509

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8

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Machine Learning-Assisted Diagnosis and Treatment of Endocrine-Related Diseases Qiuming YaoDr. Prem Prakash KushwahaWenjie Shi 28,400

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13

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Frontiers | Causal Association between Thyroid Dysfunction and Sepsis: A Two-Sample Mendelian Randomization Study

Frontiers | Causal Association between Thyroid Dysfunction and Sepsis: A Two-Sample Mendelian Randomization Study

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Sec. Systems Endocrinology

Volume 15 - 2024 |

doi: 10.3389/fendo.2024.1348248

Causal Association between Thyroid Dysfunction and Sepsis: A Two-Sample Mendelian Randomization Study Provisionally accepted

Junbin Hong

1

Lian Zhang

1

Yanni Lai

2

Xinying Chen

3

Yiting Chen

3

Jinghua Yang

3* 1

The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China

2

School of Medicine and Health, Shunde Polytechnic, Foshan, Guangdong Province, China

3

Department of Pediatrics, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China

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The causal association between thyroid dysfunction (including hyperthyroidism and hypothyroidism) and sepsis is controversial in previous studies. Therefore, we used Mendelian randomization (MR) to explore the causal association between hyperthyroidism or hypothyroidism and the susceptibility to four distinct subtypes of sepsis (streptococcal sepsis, puerperal sepsis, asthma-associated pneumonia or sepsis, and other sepsis).In our research, we conducted two-sample Mendelian randomization (MR) analyses utilizing publicly available genome-wide association studies (GWAS) data from Sakaue et al. and the Finnish database to investigate the potential causal associations between hyperthyroidism, hypothyroidism, and each of the four distinct subtypes of sepsis, in addition to reverse MR analyses of the positive results to examine the existence of reverse causality.Genetic hypothyroidism was causally related to the development of asthma-associated pneumonia or sepsis (ORIVW: 1.097, 95% CI: 1.024 to 1.174, P = 0.008); hypothyroidism was significantly associated with the development of other sepsis (ORIVW: 1.070, 95% CI: 1.028 to 1.115, P < 0.001). In addition, sensitivity analysis substantiated the robustness of these two MR findings, with no evidence of horizontal pleiotropy observed (P > 0.05). MR Egger regression analysis demonstrated no heterogeneity between instrumental variables (IVs). Inverse MR results confirmed no reverse causality between hypothyroidism and asthma-associated pneumonia or sepsis, or between hypothyroidism and other sepsis. The findings of this study also unveiled that there is no evidence of a causal link between hypothyroidism and the development of streptococcal sepsis or puerperal sepsis. Additionally, the research provided evidence indicating the absence of a causal relationship between hyperthyroidism and streptococcal sepsis, puerperal sepsis, asthma-associated pneumonia or sepsis, and other sepsis.This study identified a causal link between hypothyroidism and the occurrence of asthma-associated pneumonia or sepsis, and other sepsis, but not with the development of streptococcal sepsis and puerperal sepsis. Moreover, our findings did not reveal any causal association between hyperthyroidism and streptococcal sepsis, puerperal sepsis, asthma-associated pneumonia or sepsis, and other sepsis. Keywords:

Hyperthyroidism, Hypothyroidism, Mendelian randomization, Sepsis, thyroid dysfunction

Received:

15 Dec 2023;

Accepted:

08 Mar 2024.

Copyright:

© 2024 Hong, Zhang, Lai, Chen, Chen and Yang. This is an

open-access article distributed under the terms of the

Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,

provided the original author(s) or licensor are credited and that the

original publication in this journal is cited, in accordance with accepted

academic practice. No use, distribution or reproduction is permitted which

does not comply with these terms.

* Correspondence:

Jinghua Yang, Department of Pediatrics, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China Disclaimer:

All claims expressed in this article are solely those of the authors and

do not necessarily represent those of their affiliated organizations, or

those of the publisher, the editors and the reviewers. Any product that

may be evaluated in this article or claim that may be made by its

manufacturer is not guaranteed or endorsed by the publisher.

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, totalCites=34261, brief=FRONT ENDOCRINOL杂志医学行业,暂不明确子行业的级别不明杂志, articleType=本刊接收类型不明, medsciHeat=洋红, medsciComment=FRONT ENDOCRINOL属于国际顶级杂志,居于一线期刊,但是国内关注人数不算太多,投稿也许有些机会。, medsciExplanation=MedSci期刊指数是根据中国科研工作者(含医学临床,基础,生物,化学等学科)对SCI杂志的认知度,熟悉程度,以及投稿的量等众多指标综合评定而成。当然,具体的,您还可以结合“投稿经验系统”,进行综合判断,这更是大家的实战经验,值得分享和参考。

注意,上述MedSci期刊指数采用MedSci专利技术,由计算机系统自动计算,并给出建议,存在不准确的可能,仅供您投稿选择杂志时参考。, tags=[ImpactFactorTagDto(id=216, tagName=糖尿病, createdHits=24), ImpactFactorTagDto(id=313, tagName=临床, createdHits=14), ImpactFactorTagDto(id=20732, tagName=Endocrinology, createdHits=9), ImpactFactorTagDto(id=119, tagName=肿瘤, createdHits=6), ImpactFactorTagDto(id=865, tagName=甲状腺癌, createdHits=6), ImpactFactorTagDto(id=2683, tagName=糖尿病并发症, createdHits=4), ImpactFactorTagDto(id=332, tagName=肥胖, createdHits=4), ImpactFactorTagDto(id=2926, tagName=脂肪代谢, createdHits=2), ImpactFactorTagDto(id=41418, tagName=reproduction, createdHits=2), ImpactFactorTagDto(id=45196, tagName=case report, createdHits=2), ImpactFactorTagDto(id=516, tagName=癌症, createdHits=2), ImpactFactorTagDto(id=27798, tagName=个案, createdHits=2), ImpactFactorTagDto(id=43511, tagName=糖尿病周围神经病变, createdHits=2), ImpactFactorTagDto(id=4825, tagName=肠癌, createdHits=1), ImpactFactorTagDto(id=1821, tagName=营养, createdHits=1), ImpactFactorTagDto(id=6352, tagName=基础研究, createdHits=1), ImpactFactorTagDto(id=716, tagName=代谢, createdHits=1), ImpactFactorTagDto(id=32745, tagName=生化, createdHits=1), ImpactFactorTagDto(id=943, tagName=内分泌, createdHits=1), ImpactFactorTagDto(id=943, tagName=内分泌, createdHits=1), ImpactFactorTagDto(id=112, tagName=药学, createdHits=1)], citeScoreList=[GetImpactFactorCiteScoreListResponse(year=2017, citescore=4.0), GetImpactFactorCiteScoreListResponse(year=2018, citescore=3.51), GetImpactFactorCiteScoreListResponse(year=2019, citescore=3.4), GetImpactFactorCiteScoreListResponse(year=2020, citescore=5.1)], medsciIndexList=[GetImpactFactorMedsciIndexListResponse(year=2020, medsciHotlight=15.001), GetImpactFactorMedsciIndexListResponse(year=2021, medsciHotlight=26.683), GetImpactFactorMedsciIndexListResponse(year=2022, medsciHotlight=51.58), GetImpactFactorMedsciIndexListResponse(year=2023, medsciHotlight=42.725), GetImpactFactorMedsciIndexListResponse(year=2024, medsciHotlight=43.911)], citeScoreGradeList=[GetImpactFactorCiteScoreGradeResponse(smallClass=Medicine - Endocrinology, Diabetes and Metabolism , rank=38/211)], totalJcrAreaList=[], pmcUrl=https://www.ncbi.nlm.nih.gov/nlmcatalog?term=1664-2392[ISSN], pubmedUrl=https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Frontiers in Endocrinology[ta], article_number=3550, article_number_cn=1915, earlyWarning=null, linkOutUrl=null, isJournalMember=false, unscrambleContent=null, dayViewCount=false, endexampletyle=暂无数据)

期刊名称

FRONT ENDOCRINOL/Frontiers in Endocrinology

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1664-2392

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预警等级

MedSci期刊指数

43.911

(MedSci实时期刊指数)

| 12.8006

(5年期刊指数)

CiteScore值

5.1

h-index

68

h5-median

暂无数据

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杂志由 Frontiers Media S.A. 出版或管理

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2010

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不清楚

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Sec. Cellular Endocrinology

Volume 15 - 2024 |

doi: 10.3389/fendo.2024.1385271

This article is part of the Research Topic The Interplay between Endocrine and Immune Systems in Metabolic Diseases View all 7 articles Editorial: [The Interplay between Endocrine and Immune Systems in Metabolic Diseases] Provisionally accepted

Lan Xiao

1,2*

Weihao Wang

3

Pingping Han

4 1

Griffith Health, Griffith University, Southport, Queensland, Australia

2

Queensland University of Technology, Brisbane, Australia

3

Beijing Hospital, Peking University, Beijing, Beijing Municipality, China

4

The University of Queensland, Brisbane, Queensland, Australia

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Keywords:

Metabolic Diseases, diabetes, Immunomodulation, Immune-endocrine crosstalk, Macrophages

Received:

12 Feb 2024;

Accepted:

01 Mar 2024.

Copyright:

© 2024 Xiao, Wang and Han. This is an

open-access article distributed under the terms of the

Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,

provided the original author(s) or licensor are credited and that the

original publication in this journal is cited, in accordance with accepted

academic practice. No use, distribution or reproduction is permitted which

does not comply with these terms.

* Correspondence:

Lan Xiao, Griffith Health, Griffith University, Southport, 4222, Queensland, Australia Disclaimer:

All claims expressed in this article are solely those of the authors and

do not necessarily represent those of their affiliated organizations, or

those of the publisher, the editors and the reviewers. Any product that

may be evaluated in this article or claim that may be made by its

manufacturer is not guaranteed or endorsed by the publisher.

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